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EP4288519
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| EP4288519 - ZUSAMMENGESETZTE DREIDIMENSIONALE KULTUREN VON MENSCHLICHEN NEURONEN UND GLIA UND IHRE VERWENDUNG [Mit Rechtsklick auf diesen Link können Sie ein Bookmark anlegen.] | Status | Prüfungsantrag gestellt Status aktualisiert am 10.11.2023 Datenbank zuletzt aktualisiert am 24.03.2026 | |
| Frühere | Veröffentlichung bereits erfolgt Status aktualisiert am 03.09.2022 | Letztes Ereignis Tooltip | 03.03.2026 | Neuer Eintrag: Jahresgebühr entrichtet | Anmelder | Für alle benannten Staaten The Regents of University of California 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 / US | [2023/50] | Erfinder | 01 /
ULLIAN, Erik M. San Francisco, California 94143 / US | 02 /
KOONTZ, Mark San Francisco, California 94143 / US | 03 /
KRENCIK, Robert San Francisco, California 94143 / US | [2023/50] | Vertreter | Williams Powell 330 High Holborn London WC1V 7QH / GB | [N/P] |
| Frühere [2023/50] | Williams Powell 44 Prospect Place Bromley, Kent BR2 9HN / GB | Anmeldenummer, Anmeldetag | 22760500.3 | 25.02.2022 | [2023/50] | WO2022US17942 | Prioritätsnummer, Prioritätstag | US202163154305P | 26.02.2021 Ursprünglich veröffentlichtes Format: US 202163154305 P | US202163215179P | 25.06.2021 Ursprünglich veröffentlichtes Format: US 202163215179 P | [2023/50] | Anmeldesprache | EN | Verfahrenssprache | EN | Veröffentlichung | Art: | A1 Anmeldung mit Recherchenbericht | Nr.: | WO2022183015 | Datum: | 01.09.2022 | Sprache: | EN | [2022/35] | Art: | A1 Anmeldung mit Recherchenbericht | Nr.: | EP4288519 | Datum: | 13.12.2023 | Sprache: | EN | Die von der WIPO am 01.09.2022 in einer EPA-Amtssprache veröffentlichte Anmeldung tritt an die Stelle der Veröffentlichung der europäischen Patentanmeldung. | [2023/50] | Recherchenbericht(e) | Internationaler Recherchenbericht - veröffentlicht am: | US | 01.09.2022 | (Ergänzender) europäischer Recherchenbericht - versandt am: | EP | 24.02.2025 | Klassifikation | IPC: | C12M3/00, C12N5/00 | [2023/50] | CPC: |
C12N5/0619 (EP,US);
C12N5/0622 (EP,US);
C12N15/113 (EP);
C12N9/22 (EP,US);
G01N33/5058 (US);
C12N2310/20 (EP,US);
C12N2501/11 (US);
C12N2501/115 (US);
C12N2501/13 (EP,US);
C12N2501/155 (EP);
C12N2501/40 (US);
C12N2501/727 (EP);
C12N2503/04 (US);
C12N2506/08 (US);
C12N2506/45 (EP);
| Benannte Vertragsstaaten | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2023/50] | Bezeichnung der Erfindung | Deutsch: | ZUSAMMENGESETZTE DREIDIMENSIONALE KULTUREN VON MENSCHLICHEN NEURONEN UND GLIA UND IHRE VERWENDUNG | [2023/50] | Englisch: | ASSEMBLED THREE-DIMENSIONAL CULTURES OF HUMAN NEURONS AND GLIA AND THEIR USE | [2023/50] | Französisch: | CULTURES TRIDIMENSIONNELLES ASSEMBLÉES DE NEURONES ET DE GLIE HUMAINS ET LEUR UTILISATION | [2023/50] | Eintritt in die regionale Phase | 04.09.2023 | Nationale Grundgebühr entrichtet | 04.09.2023 | Recherchengebühr entrichtet | 04.09.2023 | Benennungsgebühr(en) entrichtet | 04.09.2023 | Prüfungsgebühr entrichtet | Prüfungsverfahren | 04.09.2023 | Prüfungsantrag gestellt [2023/50] | 04.08.2025 | Änderung durch den Anmelder (Ansprüche und/oder Beschreibung) | 04.08.2025 | Datum, an dem die Prüfungsabteilung zuständig geworden ist | Entrichtete Gebühren | Jahresgebühr | 27.02.2024 | Jahresgebühr entrichtet Patentjahr 03 | 27.02.2025 | Jahresgebühr entrichtet Patentjahr 04 | 27.02.2026 | Jahresgebühr entrichtet Patentjahr 05 |
| Ausschluss der ausschließlichen Tooltip Zuständigkeit des Einheitlichen Patentgerichts | Zu den entsprechenden Daten siehe das Register des Einheitlichen Patentgerichts | ||
| Die Verantwortung für die Richtigkeit, Vollständigkeit oder Qualität der unter dem Link angezeigten Daten liegt allein beim Einheitlichen Patentgericht. | Angeführte Dokumente: | Recherche | [X] WO2017060884 (UNIVERSITÉ DU LUXEMBOURG et al.) | [XY] US2020386742 (MOORE MICHAEL JAMES et al.) | [P] WO2016141137 (HARVARD COLLEGE et al.) | [P] ORMEL PAUL R. ET AL: "Microglia innately develop within cerebral organoids | Nature Communications", NATURE COMMUNICATIONS, vol. 9, no. 1, 9 October 2018 (2018-10-09), UK, XP093248833, ISSN: 2041-1723, Retrieved from the Internet DOI: http://dx.doi.org/10.1038/s41467-018-06684-2 | [P] WEI NIU ET AL: "Modeling genetic epilepsies in a dish", DEVELOPMENTAL DYNAMICS, WILEY-LISS INC NEW YORK , NY, US, vol. 249, no. 1, 11 July 2019 (2019-07-11), pages 56 - 75, XP071972121, ISSN: 1058-8388, DOI: 10.1002/DVDY.79 [P] DOI: http://dx.doi.org/10.1002/dvdy.79 | [X] MCCAUGHEY-CHAPMAN AMY ET AL: "Human Cortical Neuron Generation Using Cell Reprogramming: A Review of Recent Advances", STEM CELLS AND DEVELOPMENT, vol. 27, no. 24, 15 December 2018 (2018-12-15), US, pages 1674 - 1692, XP055795198, ISSN: 1547-3287, Retrieved from the Internet DOI: http://dx.doi.org/10.1089/scd.2018.0122 | [XY] GIACOMO MASSERDOTTI ET AL: "Direct neuronal reprogramming: learning from and for development", DEVELOPMENT, vol. 143, no. 14, 15 July 2016 (2016-07-15), GB, pages 2494 - 2510, XP055728015, ISSN: 0950-1991, DOI: 10.1242/dev.092163 [Y] 1-19 DOI: http://dx.doi.org/10.1242/dev.092163 | [Y] NISHA R IYER ET AL: "Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation", BIOTECHNOLOGY AND BIOENGINEERING, JOHN WILEY, HOBOKEN, USA, vol. 114, no. 2, 21 September 2016 (2016-09-21), pages 245 - 259, XP071113864, ISSN: 0006-3592, DOI: 10.1002/BIT.26074 [Y] 1-22 * figures 1-4 * DOI: http://dx.doi.org/10.1002/bit.26074 | Internationale Recherche | [XY] US2020386742 (MOORE MICHAEL JAMES et al.) [X] 1-3, 36, 59-61 * entire document *[Y] 4, 37, 38 | [Y] US2018021383 (GEORGE MATT et al.) [Y] 38 * entire document * | [Y] FREGA ET AL.: "Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays", JOVE JOURNA L, 8 January 2017 (2017-01-08), XP055965101, Retrieved from the Internet DOI: http://dx.doi.org/10.3791/54900 | [Y] XIN ET AL.: "Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling", NEUROPSYCHOPHARMACOLOG Y, vol. 44, 13 July 2018 (2018-07-13), pages 344 - 355, XP036660280, DOI: 10.1038/s41386-018-0151-4 [Y] 37 * . entire document * DOI: http://dx.doi.org/10.1038/s41386-018-0151-4 | [A] B AGYINSZKY ET AL.: "Early-onset Alzheimer's disease patient with prion (PRNP) p.Vall80lle mutation", NEUROPSYCHIATRIC DISEASE AND TREATMENT, vol. 15, 16 July 2019 (2019-07-16), pages 2003 - 2013, XP055965106 [A] 1-4, 36-38, 59-61 * . entire document * DOI: http://dx.doi.org/10.2147/NDT.S215277 | vom Anmelder | US4458066 | US4415732 | US4568649 | US5989833 | DAWSON, T. MGOLDE, T. ELAGIER-TOURENNE, C: "Animal models of neurodegenerative diseases", NAT NEUROSCI, vol. 21, 2018, pages 1370 - 1379, XP036600691, DOI: 10.1038/s41593-018-0236-8 [A] 1-4, 36-38, 59-61 * . entire document * DOI: http://dx.doi.org/10.1038/s41593-018-0236-8 | "Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease", N ENGL J MED, vol. 345, 2001, pages 956 - 963 | KAO, A. WMCKAY, ASINGH, P. PBRUNET, AHUANG, E. J. PROGRANULIN: "lysosomal regulation and neurodegenerative disease", NAT REV NEUROSCI, vol. 18, 2017, pages 325 - 333 | CHOI, S. H ET AL.: "A three-dimensional human neural cell culture model of Alzheimer's disease", NATURE, vol. 515, 2014, pages 274 - 278, XP055394768, DOI: 10.1038/nature13800 DOI: http://dx.doi.org/10.1038/nature13800 | GONZALEZ ET AL., PSYCHIATRY, vol. 23, 2018, pages 2363 - 2374 | KIM, Y. H ET AL.: "A 3D human neural cell culture system for modeling Alzheimer's disease", NAT PROTOC, vol. 10, 2015, pages 985 - 1006 | KWAK, S. S. ET AL.: "Amyloid-beta42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease", NAT COMMUN, vol. 11, 2020, pages 1377 | LEE, H. K. ET AL.: "Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells", PLOS ONE, vol. 11, 2016, pages 0163072 | YAN, Y. ET AL.: "Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells", TISSUE ENG PART A, vol. 24, 2018, pages 1125 - 1137, XP093270442, DOI: 10.1089/ten.tea.2017.0423 DOI: http://dx.doi.org/10.1089/ten.tea.2017.0423 | PENNEY, J.RALVENIUS, W. TTSAI, L. H: "Modeling Alzheimer's disease with iPSC-derived brain cells", MOL PSYCHIATRY, vol. 25, 2020, pages 148 - 167, XP036953776, DOI: 10.1038/s41380-019-0468-3 DOI: http://dx.doi.org/10.1038/s41380-019-0468-3 | HERNANDEZ-SAPIENS, M. A ET AL.: "A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1", FRONT CELL NEUROSCI, vol. 14, 2020, pages 151 | SLANZI, ALANNOTO, GROSSI, BZENARO, ECONSTANTIN, G: "In vitro Models of Neurodegenerative Diseases", FRONT CELL DEV BIOL, vol. 8, 2020, pages 328 | CHOI, S. HKIM, Y. HQUINTI, LTANZI, R. EKIM, D. Y: "3D culture models of Alzheimer's disease: a road map to a ''cure-in-a-dish", MOL NEURODEGENER, vol. 11, 2016, pages 75 | WU, Y. YCHIU, F. LYEH, C. SKUO, H. C.: "Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease", OPEN BIOL, vol. 9, 2019, pages 180177 | MOFAZZAL JAHROMI, M. A ET AL.: "Microfluidic Brain-on-a-Chip: Perspectives for Mimicking Neural System Disorders", MOL NEUROBIOL, vol. 56, 2019, pages 8489 - 8512, XP036926924, DOI: 10.1007/s12035-019-01653-2 DOI: http://dx.doi.org/10.1007/s12035-019-01653-2 | BORDONI ET AL.: "From Neuronal Differentiation of iPSCs to 3D Neuro-Organoids:Modelling and Therapy of Neurodegenerative Diseases", INT J MOL SCI, vol. 19, 2018, pages 19 | KORHONEN, PMALM, TWHITE, A. R: "3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases", NEUROCHEM INT, vol. 120, 2018, pages 191 - 199, XP085485782, DOI: 10.1016/j.neuint.2018.08.012 DOI: http://dx.doi.org/10.1016/j.neuint.2018.08.012 | CENTENO, E. G. ZCIMAROSTI, HBITHELL, A: "2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling", MOL NEURODEGENER, vol. 13, 2018, pages 27, XP055681146, DOI: 10.1186/s13024-018-0258-4 DOI: http://dx.doi.org/10.1186/s13024-018-0258-4 | POON, A ET AL.: "Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges", N BIOTECHNOL, vol. 39, 2017, pages 190 - 198, XP085214603, DOI: 10.1016/j.nbt.2017.05.009 DOI: http://dx.doi.org/10.1016/j.nbt.2017.05.009 | LEE, C. TBENDRIEM, R. MWU, W. WSHEN, R. F: "3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders", J BIOMED SCI, vol. 24, 2017, pages 59, XP055881808, DOI: 10.1186/s12929-017-0362-8 DOI: http://dx.doi.org/10.1186/s12929-017-0362-8 | SON, M. Y ET AL.: "Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells", NEUROPATHOL APPL NEUROBIOL, vol. 43, 2017, pages 584 - 603 | KIM, H ET AL.: "Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids", STEM CELL REPORTS, vol. 12, 2019, pages 518 - 531 | MIGUEL, L ET AL.: "Detection of all adult Tau isoforms in a 3D culture model of iPSC-derived neurons", STEM CELL RES, vol. 40, 2019, pages 101541, XP085865409, DOI: 10.1016/j.scr.2019.101541 DOI: http://dx.doi.org/10.1016/j.scr.2019.101541 | BOLOGNIN ET AL., ADV SCI, vol. 6, 2019, pages 1800927 | ARAI, T. ET AL.: "TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.", BIOCHEM BIOPHYS RES COMMUN, vol. 351, 2006, pages 602 - 611, XP024925727, DOI: 10.1016/j.bbrc.2006.10.093 DOI: http://dx.doi.org/10.1016/j.bbrc.2006.10.093 | NEUMANN, M. 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