Extract from the Register of European Patents

EP About this file: EP4499080

EP4499080 - 5-METHOXY-N,N-DIMETHYLTRYPTAMINE FOR THE TREATMENT OF POSTPARTUM DEPRESSION [Right-click to bookmark this link]
StatusRequest for examination was made
Status updated on  03.01.2025
Database last updated on 08.04.2026
FormerThe international publication has been made
Status updated on  07.10.2023
Formerunknown
Status updated on  24.04.2023
Most recent event   Tooltip07.01.2026New entry: Renewal fee paid 
Applicant(s)For all designated states
GH Research Ireland Limited
Joshua Dawson House Dawson Street
D02 RY95 Dublin 2 / IE
[2025/06]
Inventor(s)01 / TERWEY, Theis
10119 Berlin / DE
02 / BURKE, Conor
Laytown / IE
03 / GAFFNEY, Naoise
Dublin / IE
 [2025/06]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2025/06]Breuer, Markus
Sendlinger Straße 29
80331 München / DE
Application number, filing date23717040.227.03.2023
[2025/06]
WO2023EP57874
Priority number, dateEP2022000008427.03.2022         Original published format: EP 22000084
EP2022000008527.03.2022         Original published format: EP 22000085
EP2023015399630.01.2023         Original published format: EP 23153996
EP2023015401430.01.2023         Original published format: EP 23154014
[2025/06]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2023186827
Date:05.10.2023
Language:EN
[2023/40]
Type: A1 Application with search report 
No.:EP4499080
Date:05.02.2025
Language:EN
The application published by WIPO in one of the EPO official languages on 05.10.2023 takes the place of the publication of the European patent application.
[2025/06]
Search report(s)International search report - published on:EP05.10.2023
ClassificationIPC:A61K31/4045, A61K9/00, A61P25/24
[2025/06]
CPC:
A61K31/4045 (EP,IL,KR,US); C07D209/16 (KR); A61K9/0019 (EP,IL,KR);
A61K9/007 (EP,IL); A61P25/00 (KR); A61P25/24 (EP,IL,KR,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   ME,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2025/06]
TitleGerman:5-METHOXY-N,N-DIMETHYLTRYPTAMIN ZUR BEHANDLUNG VON POSTPARTALER DEPRESSION[2025/06]
English:5-METHOXY-N,N-DIMETHYLTRYPTAMINE FOR THE TREATMENT OF POSTPARTUM DEPRESSION[2025/06]
French:5-MÉTHOXY-N, N-DIMÉTHYLTRYPTAMINE POUR LE TRAITEMENT DE LA DÉPRESSION POST-PARTUM[2025/06]
Entry into regional phase28.10.2024National basic fee paid 
28.10.2024Designation fee(s) paid 
28.10.2024Examination fee paid 
Examination procedure28.10.2024Examination requested  [2025/06]
28.10.2024Date on which the examining division has become responsible
14.05.2025Amendment by applicant (claims and/or description)
Fees paidRenewal fee
27.02.2025Renewal fee patent year 03
06.01.2026Renewal fee patent year 04
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Cited inInternational search[IY] WO2020169851  (GH RES LIMITED et al.)
 [Y] US2022062238  (LAYZELL MARIE CLAIRE et al.)
 [A]   UTHAUG MALIN V. ET AL: "A comparison of reactivation experiences following vaporization and intramuscular injection (IM) of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting", JOURNAL OF PSYCHEDELIC STUDIES, vol. 4, no. 2, 26 March 2020 (2020-03-26), pages 104 - 113, XP093055117, DOI: 10.1556/2054.2020.00123

DOI:   http://dx.doi.org/10.1556/2054.2020.00123
by applicantWO2020169850
   MONTGOMERY, S. A.ASBERG, M: "A new depression scale designed to be sensitive to change", THE BRITISH JOURNAL OF PSYCHIATRY, vol. 134, 1979, pages 382
   LAKE, C. R.STIRBA, A. L.KINNEMAN, R. E. JRCARLSON, BHOLLOWAY, H. C.: "Mania associated with LSD ingestion", AMERICAN JOURNAL OF PSYCHIATRY, vol. 138, no. 11, 1981, pages 1508 - 9
   HENDIN, H.M.PENN, A. D.: "An episode of mania following self-reported ingestion of psilocybin mushrooms in a woman previously not diagnosed with bipolar disorder: A case report", BIPOLAR DISORDERS, vol. 23, no. 4, 2021, pages 1 - 3
   SZMULEWICZ, A. G.VALERIO, M. P.JOSE MSMITH, J. M.: "Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report", INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS, vol. 3, no. 4, 2015
   BROWN, TSHAO, WAYUB, SCHONG, DCORNELIUS, C: "A Physician's attempt to self-medicate bipolar depression with N, N-dimethyl-tryptamine (DMT", JOURNAL OF PSYCHOACTIVE DRUGS, vol. 49, no. 4, 2017, pages 294 - 296
   BADER, CYNTHIA DDAVID L. DUNNER: "Antidepressant-induced hypomania in treatment-resistant depression", JOURNAL OF PSYCHIATRIC PRACTICE, vol. 13, no. 4, 2007, pages 233 - 237
   "Melatonin and the Mammalian Pineal Gland", 1995, CHAPMAN & HALL, article "Biochemistry of the Pineal"
   SLOMINSKI RSLOMINSKI AT: "Melatonin in the Promotion of Health", 2012, CRC PRESS, article "Synthesis and Metabolism of Melatonin in the Skin and Retinal Pigment Epithelium"
   BIOCHEMICAL PHARMACOLOGY, vol. 36, pages 2235 - 2231
   BARRETT FS, J PSYCHOPHARMACOL, vol. 29, no. 11, 2015, pages 1182 - 90
   ROSEMAN L ET AL., FRONT PHARMACOL, vol. 8, 2018, pages 974
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