Extract from the Register of European Patents

About this file: EP0991664

EP0991664 - NOVEL PHARMACEUTICALLY ACTIVE COMPOUNDS INTERACTING WITH GTP-BINDING PROTEINS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  11.07.2003
Database last updated on 13.11.2018
Most recent event   Tooltip25.07.2008Change - representativepublished on 27.08.2008  [2008/35]
Applicant(s)For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Berlin / DE
For all designated states
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Jabotinsky Street 46
P.O. Box 4279
91042 Jerusalem / IL
[N/P]
Former [2000/37]For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Berlin / DE
For all designated states
Yissum Research Development Company of the Hebrew University of Jerusalem
Jabotinsky Street 46, P.O. Box 4279
91042 Jerusalem / IL
Former [2000/15]For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Berlin / DE
Inventor(s)01 / WITTINGHOFER, Alfred
Rheinlanddamm 201
D-44139 Dortmund / DE
02 / AHMADIAN, Mohammad, Reza
Rheinlanddamm 201
D-44139 / DE
03 / SCHEFFZEK, Klaus
Rheinlanddamm 201
D-44139 Dortmund / DE
04 / SELINGER, Zvi
Shlomo Zemach Street 16
96190 Jerusalem / IL
[2000/15]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[N/P]
Former [2008/35]Vossius & Partner
Siebertstrasse 3
81675 München / DE
Former [2000/15]VOSSIUS & PARTNER
Siebertstrasse 4
81675 München / DE
Application number, filing date98942551.713.07.1998
[2000/15]
WO1998EP04368
Priority number, dateEP700000111.07.1997         Original published format: PCT/EP70/00001
[2000/15]
Filing languageEN
Procedural languageEN
PublicationType: A1  Application with search report
No.:WO9902558
Date:21.01.1999
Language:EN
[1999/03]
Type: A1 Application with search report 
No.:EP0991664
Date:12.04.2000
Language:EN
The application has been published by WIPO in one of the EPO official languages on 21.01.1999
[2000/15]
Search report(s)International search report - published on:EP21.01.1999
ClassificationInternational:C07K14/47, A61K38/17, G01N33/68
[2000/15]
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2000/15]
TitleGerman:NEUE PHARMAZEUTISCH AKTIVE VERBINDUNGEN, DIE MIT GTP-BINDENDEN PROTEINEN WECHSELWIRKEN[2000/15]
English:NOVEL PHARMACEUTICALLY ACTIVE COMPOUNDS INTERACTING WITH GTP-BINDING PROTEINS[2000/15]
French:NOUVEAUX COMPOSES PHARMACEUTIQUEMENT ACTIFS INTERAGISSANT AVEC DES PROTEINES DE LIAISON GTP[2000/15]
Entry into regional phase11.02.2000National basic fee paid 
11.02.2000Designation fee(s) paid 
11.02.2000Examination fee paid 
Examination procedure07.01.1999Request for preliminary examination filed
International Preliminary Examining Authority: EP
11.02.2000Examination requested  [2000/15]
01.02.2003Application deemed to be withdrawn, date of legal effect  [2003/35]
11.03.2003Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2003/35]
Fees paidRenewal fee
31.07.2000Renewal fee patent year 03
31.07.2001Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
31.07.200205   M06   Not yet paid
Cited inInternational search[A]EP0496162  (MERCK & CO INC [US]) [A] * page 4, line 20 - line 30 *
 [XY]  - WITTINGHOFER ET AL, "The interaction of Ras with GTPase-activating proteins", FEBS LETTERS, (199706), vol. 410, pages 63 - 67, XP002058936 [X] 1-7,11-19 * the whole document * * page 65, column 2, paragraph 2; figure 2 * * page 66, column 1, paragraph L * [Y] 20-25

DOI:   http://dx.doi.org/10.1016/S0014-5793(97)00321-9
 [XY]  - M.S. MARSHALL ET AL, "A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity", EMBO JOURNAL., EYNSHAM, OXFORD GB, (1989), vol. 8, no. 4, pages 1105 - 1110, XP002058937 [X] 1-7,11-19 * the whole document * * figure 1 * [Y] 20-25
 [XDY]  - SCHEFFZEK ET AL, "Cristal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras", NATURE, (199612), vol. 384, pages 591 - 596, XP002058938 [XD] 1-7,11-19 * the whole document * * page 595, column 1, paragraph L - column 2, paragraph 1; figures 1,4 * * page 596, column 1, paragraph L * [Y] 20-25

DOI:   http://dx.doi.org/10.1038/384591a0
 [XDY]  - M.R. AHMADIAN ET AL, "Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120gap and Neutrofibrin", JOURNAL OF BIOLOGICAL CHEMISTRY., MD US, (199607), vol. 271, no. 27, pages 16409 - 16415, XP002058939 [XD] 1-7,11-19 * the whole document * * page 16414, column 1, line 4 - line 6 * * page 16414, column 2, paragraph 2 * [Y] 20-25

DOI:   http://dx.doi.org/10.1074/jbc.271.27.16409
 [Y]  - KROOK M ET AL, "Selection of peptides with surface affinity for alpha-chymotrypsin using a phage display library", JOURNAL OF CHROMATOGRAPHY A, (19950908), vol. 1, no. 711, page 119-128, XP004038957 [Y] 20-25 * the whole document *

DOI:   http://dx.doi.org/10.1016/0021-9673(95)00270-W
 [PXD]  - T. ZOR ET AL., "Rescue of mutant G-protein by substrate-assisted catalysis", EUR. J. BIOCHEM., (199710), vol. 249, no. 1, pages 330 - 336, XP002084695 [PXD] 1,8-10,26 * the whole document * * page 332, column 2; figures 1,2 *

DOI:   http://dx.doi.org/10.1111/j.1432-1033.1997.00330.x
 [A]  - T. ZOR ET AL, "m-acetylanilido-GTP, a novel photoaffinity label for GTP-binding proteins: synthesis and applications", BIOCHEM. J., (1995), vol. 306, pages 253 - 258, XP002084696 [A] 1,8-10,26 * page 258, column 1, line 15 *