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Extract from the Register of European Patents

EP About this file: EP3181560

EP3181560 - PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.10.2021
Database last updated on 03.05.2025
FormerThe patent has been granted
Status updated on  23.10.2020
FormerGrant of patent is intended
Status updated on  19.06.2020
FormerExamination is in progress
Status updated on  18.05.2020
FormerGrant of patent is intended
Status updated on  15.04.2020
FormerExamination is in progress
Status updated on  25.03.2020
FormerGrant of patent is intended
Status updated on  18.02.2020
FormerExamination is in progress
Status updated on  09.08.2019
FormerRequest for examination was made
Status updated on  19.05.2017
FormerThe international publication has been made
Status updated on  20.02.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
Shanghai Allist Pharmaceuticals Co., Ltd.
5th Floor, Building 1
1118 Halei Road & 1227 Zhangheng Road
Pilot Free Trade Zone
Shanghai, 201203 / CN
[2020/18]
Former [2017/25]For all designated states
Shanghai Allist Pharmaceuticals, Inc.
5th Floor, 1118 Halei Road Zhangilang High-Tech Park
Shanghai 201203 / CN
Inventor(s)01 / LUO, Huibing
5th floor, Building 1
1118 Halei Road & 1227 Zhangheng Road
Pilot Free Trade Zone
Shanghai 201203 / CN
02 / ZHOU, Huayong
5th floor, Building 1
1118 Halei Road & 1227 Zhangheng Road
Pilot Free Trade Zone
Shanghai 201203 / CN
03 / WANG, Shuhui
5th floor, Building 1
1118 Halei Road & 1227 Zhangheng Road
Pilot Free Trade Zone
Shanghai 201203 / CN
04 / WU, Yong
5th floor, Building 1
1118 Halei Road & 1227 Zhangheng Road
Pilot Free Trade Zone
Shanghai 201203 / CN
 [2020/26]
Former [2017/25]01 / LUO, Huibing
5th floor
1118 Halei Road
Zhangjiang High-tech Park
Shanghai 201203 / CN
02 / ZHOU, Huayong
5th floor
1118 Halei Road
Zhangjiang High-tech Park
Shanghai 201203 / CN
03 / WANG, Shuhui
5th floor
1118 Halei Road
Zhangjiang High-tech Park
Shanghai 201203 / CN
04 / WU, Yong
5th floor
1118 Halei Road
Zhangjiang High-tech Park
Shanghai 201203 / CN
Representative(s)P&TS SA (AG, Ltd.)
Avenue J.-J. Rousseau 4
P.O. Box 2848
2001 Neuchâtel / CH
[2020/48]
Former [2017/25]P&TS SA (AG, Ltd.)
Av. J.-J. Rousseau 4
P.O. Box 2848
2001 Neuchâtel / CH
Application number, filing date15828199.829.07.2015
[2017/25]
WO2015CN00540
Priority number, dateCN20141036591129.07.2014         Original published format: CN201410365911
[2017/25]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016015453
Date:04.02.2016
Language:ZH
[2016/05]
Type: A1 Application with search report 
No.:EP3181560
Date:21.06.2017
Language:EN
[2017/25]
Type: B1 Patent specification 
No.:EP3181560
Date:25.11.2020
Language:EN
[2020/48]
Search report(s)International search report - published on:CN04.02.2016
(Supplementary) European search report - dispatched on:EP29.11.2017
ClassificationIPC:A61P35/02, A61P43/00, C07D401/14, A61K31/506, C07D403/14, C07D471/04, A61P35/00
[2020/26]
CPC:
C07D471/04 (EP,US); C07D403/14 (EP,KR,US); A61K31/404 (KR);
A61K31/444 (KR); A61K31/506 (EP,KR,US); A61P35/00 (EP);
A61P35/02 (EP); A61P43/00 (EP); C07D401/14 (EP,US) (-)
Former IPC [2017/52]C07D403/14, A61K31/506, A61P35/00, C07D401/14, C07D471/04
Former IPC [2017/25]C07D403/14, A61K31/506, A61P35/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/25]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:PYRIDINAMIDOPYRIMIDINDERIVAT, HERSTELLUNGSVERFAHREN UND VERWENDUNG DAVON[2017/25]
English:PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF[2017/25]
French:DÉRIVÉ DE PYRIDINE AMIDOPYRIMIDINE, SON PROCÉDÉ DE PRÉPARATION ET UTILISATION[2017/25]
Entry into regional phase20.02.2017Translation filed 
20.02.2017National basic fee paid 
20.02.2017Search fee paid 
20.02.2017Designation fee(s) paid 
20.02.2017Examination fee paid 
Examination procedure20.02.2017Examination requested  [2017/25]
20.02.2017Date on which the examining division has become responsible
31.05.2018Amendment by applicant (claims and/or description)
13.08.2019Despatch of a communication from the examining division (Time limit: M04)
12.11.2019Reply to a communication from the examining division
27.11.2019Despatch of a communication from the examining division (Time limit: M04)
10.12.2019Reply to a communication from the examining division
19.02.2020Communication of intention to grant the patent
24.03.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
25.03.2020Fee for grant paid
25.03.2020Fee for publishing/printing paid
16.04.2020Communication of intention to grant the patent
15.05.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
26.06.2020Communication of intention to grant the patent
15.10.2020Receipt of the translation of the claim(s)
Opposition(s)26.08.2021No opposition filed within time limit [2021/44]
Fees paidRenewal fee
12.07.2017Renewal fee patent year 03
11.07.2018Renewal fee patent year 04
15.07.2019Renewal fee patent year 05
30.07.2020Renewal fee patent year 06
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU29.07.2015
AL25.11.2020
AT25.11.2020
CY25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
MC25.11.2020
MK25.11.2020
MT25.11.2020
RO25.11.2020
RS25.11.2020
SI25.11.2020
SK25.11.2020
SM25.11.2020
TR25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
LU29.07.2021
[2024/41]
Former [2024/29]HU29.07.2015
AL25.11.2020
AT25.11.2020
CY25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
MC25.11.2020
MK25.11.2020
RO25.11.2020
RS25.11.2020
SI25.11.2020
SK25.11.2020
SM25.11.2020
TR25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
LU29.07.2021
Former [2024/22]HU29.07.2015
AL25.11.2020
AT25.11.2020
CY25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
MC25.11.2020
MK25.11.2020
RO25.11.2020
RS25.11.2020
SI25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
LU29.07.2021
Former [2023/30]HU29.07.2015
AL25.11.2020
AT25.11.2020
CY25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
MC25.11.2020
RO25.11.2020
RS25.11.2020
SI25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
LU29.07.2021
Former [2023/29]HU29.07.2015
AL25.11.2020
AT25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
MC25.11.2020
RO25.11.2020
RS25.11.2020
SI25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
LU29.07.2021
Former [2022/23]AL25.11.2020
AT25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
MC25.11.2020
RO25.11.2020
RS25.11.2020
SI25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
LU29.07.2021
Former [2022/18]AL25.11.2020
AT25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
MC25.11.2020
RO25.11.2020
RS25.11.2020
SI25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
PT25.03.2021
Former [2022/10]AL25.11.2020
AT25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
RO25.11.2020
RS25.11.2020
SI25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
PT25.03.2021
Former [2021/50]AL25.11.2020
AT25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
RO25.11.2020
RS25.11.2020
SI25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
Former [2021/45]AL25.11.2020
AT25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
RO25.11.2020
RS25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
Former [2021/37]AT25.11.2020
CZ25.11.2020
DK25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
RO25.11.2020
RS25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
Former [2021/36]AT25.11.2020
CZ25.11.2020
EE25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
RO25.11.2020
RS25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
Former [2021/35]AT25.11.2020
CZ25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
RO25.11.2020
RS25.11.2020
SK25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
Former [2021/34]AT25.11.2020
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FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
RS25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
Former [2021/33]AT25.11.2020
FI25.11.2020
HR25.11.2020
LT25.11.2020
LV25.11.2020
RS25.11.2020
SM25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
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FI25.11.2020
HR25.11.2020
LV25.11.2020
RS25.11.2020
SM25.11.2020
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GR26.02.2021
IS25.03.2021
PT25.03.2021
Former [2021/28]AT25.11.2020
FI25.11.2020
HR25.11.2020
LV25.11.2020
RS25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
Former [2021/25]AT25.11.2020
FI25.11.2020
LV25.11.2020
RS25.11.2020
BG25.02.2021
GR26.02.2021
IS25.03.2021
PT25.03.2021
Former [2021/23]AT25.11.2020
FI25.11.2020
LV25.11.2020
RS25.11.2020
BG25.02.2021
GR26.02.2021
PT25.03.2021
Former [2021/22]FI25.11.2020
RS25.11.2020
PT25.03.2021
Former [2021/21]FI25.11.2020
PT25.03.2021
Former [2021/20]FI25.11.2020
Documents cited:Search[Y]US2013053409  (BUTTERWORTH SAM [GB], et al) [Y] 1-20 * [0010]-[0014]; [0025]-[0026]; [0249]; [0448]-[0452]; examples, e.g. Examples 59, 60; see also the Intermediate compounds at [0700] and [0708]; claims *;
 [Y]  - RICHARD A WARD ET AL, "Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 56, no. 17, doi:10.1021/JM400822Z, ISSN 0022-2623, (20130912), pages 7025 - 7048, (20130809), XP002734712 [Y] 1-20 * page 7031, Table 4; page 7032, Table 6; pages 7035- 7036, Table 9, entry for compound 38 *

DOI:   http://dx.doi.org/10.1021/jm400822z
International search[A]CN102482277  (DANA FARBER CANCER INST INC) [A] 1-20* the whole document *;
 [X]CN103702990  (ASTRAZENECA AB) [X] 1-17, 19, 20 * claims 1-16, description, page 2, lines 1-7, embodiments 1-60, page 82, intermediate 100 and 101, page 91, intermediate 129 and 130 (alternative synthesis) *;
 [PX]CN104761544  (CS THERAPEUTICS INC) [PX] 1-20 * description, page 18; compound (II), page 35, line 1 to page 46, line 13 *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.